Drug Release Controlled by External Electric Field
Patent Number: US9713702B2
Executive Summary:
General Description:
Incorporating conductive nanoparticles within a temperature-sensitive hydrogel offers a hybrid “smart” drug delivery system. This controlled and long-term drug release under the action of an external stimulus offer the promise of new treatments for chronic diseases that require daily injections or precise doses of medication. The conductive composition and the method of electric field-induced compound release is essential for programmed drug delivery.
Scientific Progress:
Future Directions:
Strengths:
Weaknesses:
Patent Status:
Publication PMID: 21433214, 27929180, 27088543, 22111891
Publications:
Inventor Bio: Richard N. Zare
https://web.stanford.edu/group/Zarelab/
Executive Summary:
- Invention Type: Devices/Drug Delivery
- Patent Status: US Grant
- Patent Link: https://patents.google.com/patent/US9713702B2/
- Research Institute: Stanford University
- Disease Focus: Diabetes
- Basis of Invention: Combination of conductive polymer nanoparticles and electric field for controlled drug release
- How it works: The composition comprises a conductive polymer nanoparticle, which can encapsulate an electrically-charged compound. Applying an electric field can lead to controllable release of the compound.
- Lead Challenge Inventor: Richard N. Zare
- Inventors: Richard N. Zare, Jun Ge
- Development Stage: Pre-clinical
- Novelty:
- The method of delivering a composition
- Controllable release of drugs
- Clinical Applications:
- Pain relief
- Programmed drug delivery
General Description:
Incorporating conductive nanoparticles within a temperature-sensitive hydrogel offers a hybrid “smart” drug delivery system. This controlled and long-term drug release under the action of an external stimulus offer the promise of new treatments for chronic diseases that require daily injections or precise doses of medication. The conductive composition and the method of electric field-induced compound release is essential for programmed drug delivery.
Scientific Progress:
- Validation of in vivo local release of drugs from conductive polymers in mouse models
Future Directions:
- Validation in other animal models and clinical validation
Strengths:
- The easy combination of conductive nanoparticles within a biodegradable temperature-sensitive hydrogel matrix is minimally invasive and promising for future potential clinical uses
Weaknesses:
- Needs to be tested in other animal models for reproducible results
Patent Status:
- Priority date: 2011-03-14
- Filing date: 2012-09-20
- Publication date: 2017-07-25
- Grant date: 2017-07-25
Publication PMID: 21433214, 27929180, 27088543, 22111891
Publications:
- Ge, J.; Lu, D.; Yang, C.; Liu, Z. A Lipase-Responsive Vehicle Using Amphipathic Polymer Synthesized with the Lipase as Catalyst. Macromol. Rapid Commun. 2011, 32, 546-550.
- Niloufar Hosseini-Nassab, Devleena Samanta, Yassan Abdolazimi, Justin P. Annesb and Richard N. Zare, "Electrically controlled release of insulin using polypyrrole nanoparticles," Nanoscale 2017.
- Devleena Samanta, Niloufar Hosseini-Nassaba and Richard N. Zare, "Electroresponsive nanoparticles for drug delivery on demand," Nanoscale, 2016,8, 9310-9317, DOI: 10.1039/C6NR01884J.
- Jun Ge, Evgenios Neofytou, Thomas J. Cahill, III, Ramin E. Beygui, and Richard N. Zare, Drug Release from Electric-Field-Responsive Nanoparticles , ACS Nano, vol. 6, no.1, pp. 227-233, 2012, published online November 23, 2011, DOI: 10.1021/nn203430
Inventor Bio: Richard N. Zare
https://web.stanford.edu/group/Zarelab/
